Plasmid DNA Manufacturing
High-Quality, Flexible Plasmid DNA Solutions for Advanced Therapies
Plasmid DNA (pDNA) is the backbone of many advanced therapeutic modalities, from mRNA vaccines and therapeutics to gene editing and cell therapy applications. As demand evolves, innovators require a reliable, scalable solution that integrates seamlessly into their manufacturing processes.
ReciBioPharm offers an integrated, end-to-end plasmid DNA manufacturing platform designed to support a range of advanced therapy applications, including gene editing and gene therapy, mRNA and circular RNA therapeutics, and vaccine development. Our full-circle approach ensures high-quality plasmid DNA production with optimized timelines, cost efficiency, and regulatory compliance.
Plasmid DNA Manufacturing Capabilities
Our platform delivers high-quality, scalable plasmid DNA solutions to support every stage of therapeutic development.
Rapid, scalable pDNA production to support preclinical research and development
High-quality pDNA for use as an intermediate or critical starting material in therapeutic manufacturing
Produced in cGMP production suites under controlled conditions with full material control. Ready for use in all clinical and commercial production applications
Advanced Plasmid DNA Manufacturing Processes
Our state-of-the-art facilities leverage innovative technologies to ensure consistent, high-purity plasmid DNA production with a scalable and fully compliant approach.
Upstream Capabilities
Rigorous screening and selection of optimal cell lines, growth parameter, and clones for pDNA production
Fermentation using metabolite profiling, inoculum volume control, and feed-process strategies to maximize yields and maintain product integrity
High-yielding process at both 3 L and 30 L fermentation scales to enable process optimization and tech transfer
Downstream Capabilities
Using industry-leading anion exchange and hydrophobic interaction chromatography for high-purity supercoiled plasmid production
Options include resin, membrane, and monolith purification media for tailored solutions
For applications requiring plasmid DNA as an mRNA template
Integrated Analytics & Quality Control
Qualified assays to measure plasmid DNA constructs’ identity, purity, potency, and stability
Supporting regulatory submissions from early-phase research to commercial-scale production
Tailored Solutions for Advanced Therapeutics
Plasmid DNA is a critical raw material for xRNA manufacturing and many cell and gene therapies. Whether you need supercoiled, linearized, or custom plasmid formats, our platform is designed to integrate seamlessly into your ATMP development pipeline.
Plasmid DNA Resources
Advancing Your Program Together
Your program isn’t just another project—it’s a breakthrough in the making. At Recipharm Advanced Bio, we bring deep scientific expertise, innovative thinking, and a problem-solving mindset to every partnership. Whether scaling a complex process, navigating regulatory pathways, or optimizing for commercial success, we’re here to collaborate, adapt, and deliver with excellence.
Let’s push the boundaries of possibility together and bring transformative therapies to patients faster.