xRNA Manufacturing
End-to-End xRNA Production for Advanced Therapies
xRNA-based therapies—including mRNA vaccines, therapeutic mRNA, self-amplifying RNA, and circular RNA—are transforming the landscape of medicine. Bringing these therapies to patients requires a manufacturing partner with deep expertise, integrated capabilities, and a commitment to innovation.
ReciBioPharm provides an advanced xRNA manufacturing platform, offering a seamless process from template design through final drug product. With comprehensive in-house expertise and a next-generation continuous RNA manufacturing platform, we deliver scalable, high-quality solutions tailored to the needs of emerging and established RNA modalities.
Comprehensive xRNA Manufacturing Capabilities
Recipharm Advanced Bio’s flexible xRNA platform is designed to support a wide range of RNA-based therapeutics, ensuring a reliable, scalable approach from preclinical development through commercial production.
Scalable GMP manufacturing for prophylactic and therapeutic vaccines
Precision RNA production for protein replacement, cancer immunotherapy, and regenerative medicine
Optimized manufacturing for next-generation RNA therapeutics with extended protein expression
High-purity, stable circular RNA production for novel drug modalities
Through our strategic partnership with Hongene Biotech Corporation to advance gene editing capabilities, we have integrated Hongene’s cutting-edge sgRNA technology with Recipharm Advanced Bio’s comprehensive manufacturing services. This collaboration streamlines and accelerates the drug development processes for gene editing therapies.
Advanced xRNA Manufacturing Processes
- Plasmid DNA template production through our integrated plasmid manufacturing platform
- Chemoenzymatic synthesis for high-yield, high-purity production
- Optimized in vitro transcription (IVT) with scalable batch and continuous process options
- Chromatography-based purification to achieve high yield and purity
- Enzymatic capping and polyadenylation strategies to optimize stability
- Comprehensive analytical testing for RNA integrity, potency, and purity
- End-to-end xRNA production under GMP conditions
- Seamless scale-up from early-phase to commercial volumes
- Flexible xRNA manufacturing models, including batch and continuous processing
Industry-Leading Continuous xRNA Manufacturing
With grant support from the FDA’s Center for Biologics Evaluation and Research (CBER) Advanced Technology Program and in collaboration with MIT, Recipharm Advanced Bio has pioneered a groundbreaking continuous xRNA manufacturing platform.
Sequence to final product in less than 4 months
Plasmid DNA: A Critical Foundation for xRNA Manufacturing
High-quality plasmid DNA is the foundation of xRNA production, serving as the template for in vitro transcription. As a leading manufacturer of GMP plasmid DNA, Recipharm Advanced Bio ensures a seamless transition from pDNA synthesis to xRNA production, optimizing timelines and quality at every stage.
- Integrated plasmid DNA manufacturing platform with options from research grade to full GMP plasmid solutions
- Scalable production with high-purity circular and linearized plasmid formats
- In-house analytics and regulatory compliance to support RNA-based therapeutics
Lipid Nanoparticle Encapsulation Expertise
For xRNA-based therapies, effective delivery is just as critical as the drug itself. Our expertise in lipid nanoparticle (LNP) mixing and TFF processes allows us to support your therapy from plasmid DNA manufacturing through xRNA encapsulation which helps optimize stability, encapsulation efficiency, and drug delivery. By integrating plasmid DNA production, RNA synthesis, and advanced LNP formulation technologies, we streamline the path from sequence to final drug product.
Learn more about our integrated lipid nanoparticle solutions and how they enhance the development of RNA-based therapeutics.
Learn MorexRNA Manufacturing Resources
Advancing Your Program Together
Your program isn’t just another project—it’s a breakthrough in the making. At Recipharm Advanced Bio, we bring deep scientific expertise, innovative thinking, and a problem-solving mindset to every partnership. Whether scaling a complex process, navigating regulatory pathways, or optimizing for commercial success, we’re here to collaborate, adapt, and deliver with excellence.
Let’s push the boundaries of possibility together and bring transformative therapies to patients faster.